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Those with chronic myelogenous leukemia have a piece of chromosome 9 connected to chromosome 22 in the cancerous cells. This connection in chromosomes in referred to as a 9:22 translocation.
Discuss why RNA polymerases are not able to correct base errors during replication or transcription. Describe the biological consequences of the protein that may develop in this case.
The blood disease beta-thalassemia results from homozygosity for a defective allele in the gene coding for the beta hemoglobin subunit. Homozygotes for the beta-thalassemia allel die in childhood.
If both parents must have a point mutation in their CF genes in order to create a child with CF, how common do you think the disease is in the population? Explain.
Make a mutation in the DNA sequence by changing only one base pair that you expect would have no affect on the protein that is made.
A particular DNA mutation produces a UGA stop codon in the middle of the RNA coding for a specific protein. A second mutation in the cell causes a single nucleotide change in a tRNA.
What are the various types of genetic mutations in terms of how they occur, as well as their effects on the DNA sequence and the resulting protein product.
Two phages with genotype x+ y - and x- y + are crossed. What are the genotypes of the possible recombinant types? Are any of them wild-type.
An autosomal dominant disease (Huntington disease) is being transmitted in the pedigree below. A two-allele marker (designated 1 and 2) has been typed for each family member.
Two new hair dyes A and B were tested in the Ames test. Both were tested with and without liver homogenate. Two auxotrophic strains of bacteria were used, one in which the auxotrophy was caused by a
In a population, 30% of the females are pure dominant, 60% are hybrid, and 10% are pure recessive. If a pure recessive male mates with a random female and their first offspring has the dominant trai
Suppose you are given the task of genetically modifying a mouse so that its skin cells secrete a bitter tasting protein that will protect it from predation.
Of the genes that code for CAK, wee1, and cdc25, which would you expect, when mutated, to stop a cell from continuing to divide? Which would you expect, when mutated, to cause the cell to proliferat
Determine the degree of drift affecting a population.
Now consider another locus, with the following fitnesses. Let the initial q=.25, and assume random mating. Ignore mutation, migration, and genetic drift.
ou cross an aa bb mutant plant with an AA BB wild type. What would the F2 segregation ratio be (wild type to mutant) if.
Consider a pair of homologous chromosomes heterozygous for three genes (e.g., ABC/abc) during prophase I of meiosis. Let the sister chromatids of one homolog be numbered 1 and 2 (ABC).
But the same thing did not work for problem #1. Adding 100 to the recombinant numbers resulted in an answer of 1.2, which is not correct. Nor is the correct answer 1.1, which would make up the dista
You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds.
Mr. Green is heterozygous for one autosomal gene pair, "Bb", and he carries a recessive x-linked gene "d". What proportion of his sperms will be "bd".
A transformation experiment is performed with a donor strain that is resistant to four drugs: A, B, C, D. The recipient is sensitive to all four drugs.
In haploid yeast, a cross between arg- ad- nic+ leu+ and arg+ ad+ nic- leu- produces haploid sexual spores, and 20 of these are isolated at random. The resulting cultures are tested on various media
In garden peas, yellow seed color is dominant over green, and round seed shape dominant over wrinkled. What phenotypic ratio can be expected in F2 from a cross between pure yellow and round with gre
How many different types of mating are possible.
Fur colour in the babbit, a furry little animal and popular pet, is determined by a pair of alleles, B and b. B/B and B/b babbits are black, and b/b babbits are white.