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explain the absorption of itraconazole capsulesit is decreased with concurrent use of drugs that reduce gastric acidity such as antacids h2-receptor
adverse effects the most common adverse effects of itraconazole are dose-related nausea and abdominal discomfort rash and serious hepatic toxicity
define itraconazoleitraconazole is fda-approved for treatment of blastomycosis histoplasmosis non-meningeal and aspergillosis in patients who are
explain itraconazoleit has a broader spectrum of activity than fluconazole it is active against a wide variety of fungi including cryptococcus
define fluconazole it is a weaker inhibitor of cyp3a4 than itraconazole or ketoconazole but may still increase serum concentrations of drugs
explain adverse effects fluconazole is generally well tolerated gastrointestinal distress and rash can happen stevens-johnson syndrome anaphylaxis
fluconazolefluconazole is active against most candida species other than c krusei which is intrinsically resistant and many strains of c glabrata
azolessystemic azole antifungals currently available in the us contain fluconazole diflucan and others itraconazole sporanox voriconazole vfend and
explain lipid formulationsthree lipid formulations of amphotericin b are marketed in the us amphotericin b lipid complex ablc abelcet liposomal
explain nephrotoxicitynephrotoxicity is the major dose-limiting toxicity of amphotericin b deoxycholate sodium loading with normal saline may
fungal infectionsintravenous infusion of amphotericin b deoxycholate frequently causes fever and chills and sometimes headache nausea vomiting
conventional amphotericin amphotericin b deoxycholate fungizone and others the old non-lipid formulation of amphotericin is by far the least
polyenes amphotericin bamphotericin b products are the only polyenes currently available for systemic treatment of fungal infections nystatin
use of repellentsavoidance and early removal of ticks are the first steps in prevention of lyme disease in highly endemic areas when an engorged
explain post-lyme disease syndrome some treated patients whose objective manifestations of lyme disease have resolved with antibiotic treatment
explain arthritisarthritis - oral therapy with doxycycline or amoxicillin for 28 days is usually effective for treatment of lyme arthritis patients
explain cardiac diseasecardiac conduction abnormalities associated with lyme disease are generally self-limited patients with minor cardiac
explain neurologic diseasefor patients with facial nerve palsy alone oral doxycycline or amoxicillin may be effective patients with other neurologic
erythema migrans oral antibiotic therapy shortens the duration of the rash and generally prevents development of late sequelae among the 3 drugs used
explain prophylaxis of lyme diseaseno vaccine is currently available to prevent lyme disease in humans avoidance of ticks and use of tick repellents
diagnosis of lyme diseasein endemic areas lyme disease is diagnosed by recognition of erythema migrans igg antibodies to b burgdorferi are usually
explain lyme diseasethe disease - about 70-80 of patients infected by b burgdorferi develop the characteristic skin lesion erythema migrans which
treatment of lyme diseaselyme disease in north america is caused by the spirochete borrelia burgdorferi which is transmitted to humans by ixodes
explain prosthetic device infections some infectious disease specialists recommend antimicrobial prophylaxis before process in patients with vascular
explain endocarditisthe risk of endocarditis is considered high in patients with last bacterial endocarditis prosthetic heart valves complex cyanotic