Assignment task:
Patient scenario:
Your patient is Mrs. Genevieve Langton who is a 62-year-old female. She experiences atrial tachycardia and has been prescribed a beta-blocker (your chosen drug: metoprolol) for rate control. She doesn't like swallowing whole tablets and would normally crush tablets or open capsules and mix them in a beverage to hide the taste (her beverage of choice being fizzy tonic water and orange juice). Mrs. Langton has several questions about her new medication:
If Mrs. Langton experiences renal or hepatic impairment in the future, apply your knowledge of pharmacokinetics to explain which of the components of 'ADME' would be affected by this medicine, and how this impacts the patient.
Applying your knowledge of pharmacokinetics, explain whether mixing the crushed medication with orange juice or fizzy tonic water will impact the clinical effects Mrs. Langton experienced.
Mrs. Langton sometimes takes antacids. Applying your knowledge of functional groups and ionization, explain the impact on the absorption of the medicine when it is taken with versus without antacids. What are the important considerations about how this medicine is absorbed, distributed, metabolized and excreted?
1. What are the important considerations about how this medicine is absorbed, distributed, metabolized and excreted? Reference
2. Are there important considerations around food eaten at the same time? Reference
3. Will kidney or liver conditions have an impact on the recommended dosage, duration of action etc. Reference