Why in the preparation of a karyotype analysis is the use of a substance like colchicine interesting?
Colchicine is a substance that disallows the formation of microtubules and therefore of the spindle fibers in cell division. Under the action of this drug the cells interrupt division at metaphase and the anaphase does not happen. Thus the use of colchicine in the study of karyotypes is interesting because chromosomes will be seen condensed and replicated.