Why in the preparation of a karyotype analysis is the use of a substance like colchicine interesting?
The Colchicine is a substance that disallows the formation of microtubules and thus of the spindle fibers in cell division.
Underneath the action of this drug the cells interrupt division at metaphase and the anaphase does not occur. Thus the use of colchicine in the study of the karyotypes is interesting because chromosomes will be seen replicated and condensed.