Question: Why is it important to avoid repeats (e.g., ATATATATAT) and runs (e.g., AAAAAA) when designing primers? (Choose the most correct answer) Question options: a) It is harder to design. b) It promotes the probability of mispriming and increases the likelihood of homo- and hetero-dimer formation. c) It causes the Tm of primers to be too high d) It promotes primers binding backwards to the DNA template (5'end of primer to 5' end of DNA template). e) It depletes the availability of dNTPs.