Which unwanted immune response is inherently more difficult, Biology

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Which unwanted immune response is inherently more difficult

Which unwanted immune response is inherently more difficult to block or attenuate, and why?

a. Transplantation, because they have poorly-defined antigens
b. Autoimmune diseases, because one cannot predict when it will happen
c. Transplantation, because they have well-defined antigens
d. Graft-versus-host diseases, because they happen spontaneously
e. none of the above

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