Question: Which statements are true regarding barbiturates? Select all that apply.? Monoamine oxidase inhibitors (MAOIs; antidepressants) result in a longer duration of action of barbiturates. Decreased central nervous system (CNS) depression occurs when administered with alcohol, antihistamines, benzodiazepines, opioids, and tranquilizers. The long-term use of barbiturates can lead to harmful effects on sleep due to the prolongation of rapid eye movement (REM) sleep.? An overdose of barbiturates typically leads to respiratory arrest, coma, and death.? Barbiturates are a type of sedative-hypnotic.