A 55 y/o male presents to your clinic for a scheduled follow-up. He has a 15 year history of type 2 diabetes with HbA1c of 8, hypertension, hyperlipidemia, and CAD with a MI last year. You understand that this uncontrolled diabetes is associated with the HTN, HLD, and CAD/MI.
Which statement below best describes this association of diabetic vascular complications?
- Inflammatory induced cytotoxic T-lymphocytes leads to degredation of the endothelial wall
- Inflammatory induced inhibitor of vascular endothelial growth factors (VEGFs) at eh basement membrane
- Vascular smooth muscle in the extracellular matrix (ECM) is inhibited by chronic hyperglycemia
- Hyperglycemic enhanced formation of advanced glycation end products (AGEs) setting off a cascade of vascular inflammatory events