Problem:
A 45-year-old woman was prescribed doxepin 10 mg/night for insomnia. She reports that it helped only a little, so she has been increasing the dose, up to 100 mg/night, as an attempt to increase the hypnotic effects (with some success). She also reports dizzy spells and constipation. Which property does doxepin exhibit in higher doses that could be the cause of these side effects? Need Online Tutoring?
A. Inhibiting reuptake of serotonin and norepinephrine B. 5HT2A and 5HT2C antagonism C. Alpha 1 adrenergic and muscarinic 1 antagonism D. 5HT2A and 5HT2B antagonism