Which of the following would most likely cause a mutation with the greatest deletrious effect?
A. An insertion of a nucleotide triplet into a DNA strand thatcodes for an mRNA
B. A deletion of a nucleotide triplet from a DNA strand thatcodes for an mRNA
C. A single substitution of a nucleotide in a DNA strand that,when transcribed, results in a change in the nucleotide occupyingthe third codon position in an mRNA
D. A single substitution of a nucleotide in a DNA strand,that, when transcribed, results in a change in the nucleotideoccupying the first codon position in an mRNA
E. A single addition of a nucleotide in a DNA strand thatcodes for an mRNA