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Which of the following statements regarding geriatric

Which of the following statements regarding geriatric pharmacotherapy are correct? I. First-pass metabolism decreases with age; thus less nitrates, such as isosorbide dinitrate, would be necessary to exert their desired effect. II. Amitriptyline (Elavil) would be an excellent antidepressant to initiate in an 85-year-old patient with depression III. Phase I hepatic metabolism slows down with age.

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