Which of the following factors contribute to the large negative ΔG° for the hydrolysis of mixed anhydrides of phosphoric and carboxylic acids such as acetyl phosphate and 1,3-bisphosphoglycerate:
A. Destabilization of the reactant due to bond strain caused by electrostatic repulsion
B. Stabilization of the products by ionization
C. Competing resonances in the reactant relieved by resonance stabilization of the products
D. Entropy effects arising from hydrolysis and ionization
Choose the correct answer:
| all of the above |
| all except A |
| all except B |
| all except C |
all except D
|