The table below gives the Z scores for four different marker loci (A, B, C and D) with respect to possible linkage to a monogenic, fully penetrant trait.
|
E
|
0
|
0.05
|
0.1
|
0.15
|
0.2
|
|
Z(A)
|
-3.0
|
-2.0
|
-1
|
0
|
0.3
|
|
Z(B)
|
0.1
|
0.2
|
1.0
|
0.6
|
0.3
|
|
Z(C)
|
4.0
|
3.0
|
2.0
|
0.8
|
0.2
|
|
Z(D)
|
∞
|
2.0
|
4.0
|
4.2
|
2.5
|
a. Which markers is/are significantly linked to the trait allele anywhere within 0≤È≤0.2?
b. Which marker appears to be closest (fewest cM away) to the trait allele?
c. Which markers, if any, definitely is/are NOT linked to the trait allele specifically at È=0?
(they may be linked at other values of È)
d. For which markers, if any, can we make no definite conclusion about linkage?