Question: Which statement best describes the negative impacts of too little sleep? Multiple choice question. A lack of sleep is associated with poor health of body systems, leading to an increased risk of type 2 diabetes, mental health issues, stroke, and even premature death. A lack of sleep negatively impacts the cardiovascular system, but has little impact on other body systems. A lack of sleep negatively impacts the endocrine and digestive systems, but has little impact on other body systems. A lack of sleep is associated with poor health of body systems, leading to an increased risk of some forms of cancer, elevated blood cholesterol levels, thyroid disorders, and even premature death.