When the level of AMP is high, this shows the requirement for more ATP synthesis. AMP stimulates PFK increases the rate of glycolysis and inhibits fructose 1 and 6- bisphosphatase turning off gluconeogenesis. Equally, when ATP and citrate stages are high, this signals which no more ATP needed to be made. ATP and citrate inhibit PFK, reducing the rate of citrate and glycolysis stimulates fructose 1, 6- bisphosphatase, raise the rate of gluconeogenesis.