Question: At what point should the PMHNP consider switching to clozapine for treatment resistant schizophrenia? Question options: A) When the patient refuses long acting injectable medications. B) After an adequate trial, but inadequate response to two different second-generation antipsychotics and one first-generation antipsychotic. C) Clozapine should never be used as monotherapy, it should only be used to augment the effects of another antipsychotic in the context of treatment resistance. D) After adequate trials of at least two second generation antipsychotics and a mood stabilizer.