Question: Tricyclic antidepressants are an older class of antidepressants that while effective, have more side effects than some of the newer classes of antidepressants. Which of the following is true regarding tricyclic antidepressants? TCAs are a good choice in patients that are overweight because they promote weight loss. TCAs are a good choice in patients with a seizure disorder. TCAs have a wide therapeutic index and are safe across a wide dosing range The most significant risks related to TCA use are cardiac conduction disorders.