Question: Which of the following is true regarding chronic opioid exposure and tapering? Looking for Assignment Help? Patients can loose their tolerance to respiratory depression quickly after tapering. If they re-initiate opioids, it should be at a low dose to avoid accidental overdose. Tapering does not apply to opioid naive patients who leave the hospital after a surgical procedure with a new prescription for opioids. Opioid withdrawal only occurs in patients taking above 50 mg PO morphine equivalents for a long period of time. Tapering guidelines are consistent with recommendations for how to taper?