Question: Consider the role and responsibilities of an Institutional Review Board (IRB) and the Institutional Animal Care and Use Committee (IACUC). Which of the following are true of an Institutional Review Board (IRB)? Select all that apply. Answer An IRB is not responsible for protecting human research subjects. An IRB is not regulated by any overseeing agency, such as the federal government. An IRB examines all the research materials to determine if the research participants are adequately protected. An IRB's consideration is based primarily on weighing the risks and benefits of the research.