Assignment task: Jane Johnson, a 48-year-old female with a diagnosis of diabetes 6 years ago, was admitted to the hospital for gastric bypass surgery. ?
Mrs. Johnson is now 7 days post-operative with a wound infection that has caused the wound to dehisce. ?
Her current antibiotic regimen includes vancomycin IV 500mg twice a day. ?
Today, it was determined that she has a systemic fungal infection, and the healthcare provider prescribes amphotericin B to be administered IV @ 1mg/kg/day to be started following a test dose of 15mg in 50 ml infused over 30 minutes. ?
The nurse reviewing the prescription also notes to hold the amphotericin B if the patient's BUN is elevated above 40mg/dl.
Questions:
Q1. The unlicensed personnel weighs Mrs. Johnson and documents it in the chart as 326 pounds. What is the patient's daily dose of amphotericin B?? (Show your calculations)
Q2. What considerations or precautions should the nurse take during infusion of the test dose of amphotericin B??
Q3. What are the serious adverse effects of amphotericin B for which the nurse should monitor in the client, and how can the nurse minimize the risk of these adverse effects?