You perform DNA microarray experiments on cancer cells at different time points (0, 6, and 12 hours) following the addition of a novel anti-cancer drug. You obtain the following normalized and scaled microarray data for the genes Myc, p53, and Ras.
Gene Name 0 hr 6 hr 12 hr
Myc 1.0 0.2 -1.2
P53 -1.1 0.4 0.7
Ras 1.3 -1.4 0.1
a. Use the Euclidean distance method to calculate the following distance matrix:
Gene Myc p53 Ras
Myc
P53
Ras
b. Which two genes would be clustered together ?rst using the hierarchical clustering method'?
c. If we are using the Complete Linkage cluster method, what is the new distance between the remaining (unclustered) gene and the new gene cluster generated in part (b)?