Problem
• Tay-Sachs is an autosomal recessive disease that is fatal in early childhood. In the Eastern European Jewish population, it occurs in about 1 in every 3,500 births. Assuming the population is in Hardy-Weinberg equilibrium, what is the frequency of carriers in this population? Show how you calculated this number.
• For Tay-Sachs disease, what is the relative fitness of each of the three genotypes? What is the mean fitness of the population described above, which has one case of Tay-Sachs disease for every 3,500 births?