Question: The higher incidence of AKI in elderly persons can be potentially attributed to the following: Need Assignment Help?
A) comorbidities that accumulate with age may facilitate AKI (e.g., renovascular disease, congestive heart failure); B) comorbidities may necessitate procedures, drugs or surgery that function as kidney stressors and nephrotoxins; C) the kidney undergoes age-dependent structural and functional alterations over time (Box 1).9-22 The result of the latter is a reduced GFR at baseline and a diminished kidney reserve in the setting of pathophysiological challenges, lending elderly patients very vulnerable to acute stress and more likely to develop clinically relevant AKI