Question: A 68-year-old man presents with progressive difficulty swallowing, along with voice changes and shortness of breath. He reports that his symptoms began with occasional slurred speech, but have worsened over the past few months. On examination, you note fasciculations in his tongue, as well as weakness and atrophy of the muscles in his face and neck. His gag reflex is absent. Which of the following is most closely associated with this patient's condition? Question Answer a. Upper and lower motor neuron findings on physical examination b. White matter plaques on T2-weighted MRI c. All options are true d. The majority of cases are inherited due to a defective superoxide dismutase 1 gene (SOD1). e. Internuclear ophthalmoplegia is a common finding