Assignment task: Describe what is known about the Hippo/ Salvador-Warts-Hippo signaling pathway, including how and when it was first identified, an example cell type where its activity is required, and the effects of loss of activity. The last section can reference human disease if relevant. Provide appropriate citations crediting the original discoveries.
Provide a specific example of experiments that support claims that the signaling pathway directly regulates both cell division and differentiation. Cite at least two primary research papers published in reputable scientific journals (no pre-prints) that showed experimental evidence confirming that the signaling pathway regulates division or differentiation. Explain how the claims made in these research studies showed that the signaling pathway was involved in each process.