Problem 1: Our DNA is subject to mutations on a daily basis. Why do most mutations that occur in the genome of organisms escape detection and not elicit a deleterious effect? Why does the child of someone with cancer not necessarily develop cancer?
Problem 2: Why do you think gene regulation is more complex in a multicellular organism versus a single-celled organism? Why is it harder to study gene regulation in eukaryotes?
Problem 3: What is a spontaneous mutation, and why are spontaneous mutations rare?
Problem 4: Why would a mutation in a somatic cell of multicellular organism escape detection?
Problem 5: Why is gene regulation more complex in a multicellular eukaryote than in a prokaryote? Why is the study of this phenomenon in eukaryotes more difficult?
Problem 6: Provide a brief description of two different types of histone modification.
Problem 7: Where are the major regulatory points in the cell cycle?
Problem 8: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to behave as a recessive gene?
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