What happen if ionic conditions in the er lumen were change, Biology

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What happen if ionic conditions in the er lumen were change

Problem: Certain cells are specialized for secreting products rapidly and on demand, such as cells that must secrete hormones. These cells are going to be secreting large amounts of proteins through the regulated secretory pathways. What do you think would happen in these cells if the ionic conditions (pH) in the ER lumen were to change to resemble those of the trans Golgi network?

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