Assignment
Read pages 1-5 of the case study, "Statins Stat!", and answer the following questions:
a. Why are high density lipoproteins (HDLs) considered the "good cholesterol"? In your answer explain specifically what HDLs do that cause it to be considered the "good cholesterol".
b. Why are low density lipoproteins (LDLs) considered the "bad cholesterol"? In your answer explain specifically what LDLs do that cause it to be considered the "bad cholesterol".
c. What is the role of the phospholipid monolayer at the outer surface of lipoprotein particles? (Question 1 of case study)
d. Why are cholesterol, cholesteryl esters, and triglycerides preferentially contained inside lipoprotein particles? (Question 2 of case study)
e. What are the two sources of cholesterol in the human body?
f. What is a "committed step" in a biochemical pathway? (Question 3 of case study)
g. Looking at Figure 4 of case study (the reaction pathway from acetyl-CoA), which enzyme is likely to be the target of the statin mevastatin? (Question 6 of case study)
h. What are four ways that HDL levels can be increased in the body?
i. What type of inhibitor (non-competitive OR competitive) are statins with respect to HMG-CoA reductase enzyme activity? Explain why.
j. How were cholesterol-lowering statin drugs first discovered?
Format your assignment according to the give formatting requirements:
a. The answer must be double spaced, typed, using Times New Roman font (size 12), with one-inch margins on all sides.
b. The response also includes a cover page containing the title of the assignment, the course title, the student's name, and the date. The cover page is not included in the required page length.
c. Also include a reference page. The references and Citations should follow APA format. The reference page is not included in the required page length.