What are pirna clusters
Problem: What are piRNA clusters? What is produced from these loci?
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Question: Which of the following best describes the primary function of the spindle checkpoint?
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Would you expect more staining in metacentric chromosomes or telocentric chromosomes? Why?
Li et al (2009) identified new introns in some populations of Daphina pulex. They found most of the new introns in Oregon populations
Ago3 typically binds sense piRNAs that are the same as TE transcripts. Why is Ago3 necessary for the piRNA pathway?
Explain why 5-alpha-reductase inhibitors may be a preferred therapeutic strategy over using anti-androgen receptor modulators to treat prostate cancer.
Question: Briefly describe the difference between adaptive response and acquired resistance to RAF inhibitors.
Describe two approaches you would take to identify targeted drugs for XAX, and how you would perform preclinical tests of these drugs.
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