Problem: Which of the below findings about antidepressant effectiveness is NOT true? Research on antidepressant medication has overrepresented their effectiveness and underrepresented their negative and questionable outcomes. High rates of placebo response in studies of antidepressant medication have been a concern for a while. Antidepressants in general have been shown to be about as effective as placebo in various studies. In outcome research, antidepressant medications have consistently proven to be more effective than placebo in many trails.