Unlike DNA binding domains and dimerization domains, no general structural motifs have since been identified in the activation domains of diverse transcription factors. Some parts of activation domain are as follows:
? Acidic activation domains are rich in acidic amino acids aspartic and glutamic acids. For instance, mammalian glucocorticoid receptor proteins have this kind of activation domain;
? an glutamine-rich domains for instance as in SP1 transcription factor;
? An proline-rich domains for example as in c-jun transcription factor