Biochemical pathway for dopamine and its derivatives. Non-peptide transmitters are synthesized in the terminal and packaged into synaptic vesicles by specific high affinity transporters. Vesicular amine transporter (VAT) packages DA into vesicles. How is transmitter action terminated? Example: DA. Vesicular amine transporter (VAT) package DA into vesicles. Regulation of transmitter release: how does the neuron regulate its release? Biochemical feedback regulation or end product inhibition. What are the most common neurotransmitters in the brain?