1) Write a brief note on the following:
a) PDB file format
b) STAR file format
c) CIF file format
d) mmCIF file format
2) Explain how we can visualize 3D coordinate file a protein; explain several model of representing the small molecule or the crystal structure?
3) Discuss the database system involving the hierarchical database system, network model, relational model and the object based model?
4) Explain what is meant by the crystallography databases, elaborate and explain the following terms:
a) ICSD
b) CSD
c) PDB
5) Explain how can we synthesize the chemical molecules interest by the solid phase synthesis?
6) Explain how can we synthesize the chemical molecules interest by the solution phase synthesis?
7) Explain the meaning of the virtual screening explain its importance?
8) Explain how you can develop the combinatorial library; write down the approaches of the optimization?
9) Explain the ligand based drug designing (LBDD) in brief?
10) Explain the term lead finding and the optimization?