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Summarize:- Essay on pathophysiology of acute myelogenous leukemia from an art... success check mark We found a match with an answer Question Essay on pathophysiology of acute myelogenous leukemia from an article 12 Answer & Explanation Solved by AI Certainly! Acute Myelogenous Leukemia (AML) is a complex hematologic disease characterized by the rapid proliferation of abnormal myeloid cells in the bone marrow and blood. Pathophysiologically, it involves a series of genetic and molecular alterations that disrupt normal hematopoiesis. Genetic and Molecular Basis AML is primarily caused by chromosomal translocations and genetic mutations that affect the normal differentiation and proliferation of myeloid precursor cells. The most common chromosomal abnormality in AML is the translocation between chromosome 8 and 21, leading to the formation of an abnormal fusion protein that blocks differentiation of myeloid cells. Other frequent mutations involve genes like FLT3, NPM1, and CEBPA. These mutations confer growth advantages to the leukemic cells, allowing them to expand unchecked. Disruption of Hematopoiesis Under normal circumstances, hematopoietic stem cells in the bone marrow differentiate into various blood cell lineages. In AML, the genetic mutations impair this differentiation process, resulting in the accumulation of immature myeloid blasts. These blasts are unable to perform the normal functions of mature white blood cells such as: Need Assignment Help?