A major difficulty in investigating the properties of pancreatic serine proteases is that these enzymes, being proteins, are self digesting. The problem is less severe for solutions of chymotrypsinthan than for solutions of elastase or trypsin.
Suggest an explantion for this observation?
(Do not consider the zymogen activation steps (Chymotripsinogen to chymotrypsin) but only the final active form of these proteins.)