Problem: Which step is necessary when preparing two medications in one syringe? Select all that apply. One, some, or all responses may be correct. Check the compatibility of the drugs before beginning preparation. Ensure that the intermediate-acting or long-acting insulin is drawn into the syringe first. Check the type, concentration, expiration date, appearance, and temperature of the medications. Roll the vial or pen between the palms of the hands or invert the vial several times to mix suspensions thoroughly. Check the insulin order and the calculations of the preparation with the primary health care provider before administering medication. Confident Not Sure. Need Assignment Help?