Question: Which of the following statements is true regarding the extent of drug absorption? Need Online Tutoring? A. After oral ingestion, the absorption of a drug may be incomplete. B. Drugs that are too lipophilic cannot cross the lipid cell membrane. C. Drugs that are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell. D. P-glycoprotein is an efflux transporter that is present in the enterocytes and enhances drug absorption. E. Grapefruit juice activates P-glycoprotein, leading to substantial inhibition of drug absorption.