Question: Which statements about the pharmacodynamic and pharmacokinetic of digoxin toxicity are correct? Select all that apply. Toxicity can occur easily due to the narrow therapeutic range of digoxin. The half-life and duration of digoxin are very long. Absorption of oral digoxin is not affected by food. Digoxin increases myocardial contraction, which increases cardiac output. Digoxin increases the heart rate and cardiac output. Oral digoxin begins to work in 30 minutes to 2 hours.