Question: Which statement is true about intermediate-acting benzodiazepines?? The onset and duration of action is longer than long-acting benzodiazepines.? Intermediate-acting benzodiazepines are less effective when taken with other central nervous system (CNS) depressants.? Intermediate-acting benzodiazepines have a typical onset of 1-2 hours. Intermediate-acting benzodiazepines cause a decreased CNS depressive effect when taken with barbiturates.?