Somewhere between 30% and 50% of all drugs on the market target a G protein-coupled receptor. For each agent,
- Write an in-depth description of the agent and its mechanism of action.
- Are they agonists or antagonists?
- What GPCR or GPCRs do they bind?
- What is the endogenous ligand? Include in your descriptions the sources of the agents.
- Were they isolated from nature, stumbled upon randomly, or intentionally synthesized?
- When and by whom? If one of the agents is a "dirty drug," be sure to mention other sites of action besides the GPCRs.
- If you can find the information, what signal transduction pathway is activated or inhibited by each drug?
- What are the applications of your agents? Are they only used in research or does either have a clinical use?
Pharmacological agent and target
staurosporine and protein kinases
Signal transduction pathways represent a wealth of potential targets for pharmacological intervention.
- Write an in-depth description of agent (staurosporine and protein kinases) and its mechanism of action. Include in your description the source of the agent.
- Was it isolated from nature, stumbled upon randomly, or intentionally synthesized?
- When and by whom?
- If the agent is a "dirty drug," be sure to mention other sites of action.
- What are the applications of the agent?
- Is it only used in research or does it have a clinical use?
Be sure to cite all of your references.
NO DIRECT QUOTES! Write a single, cohesive response.