Situation in which a closed loop negative feedback system is converted to an open loop system?
A. A disease that destroys all the adenylyl cyclase and all the cAMP in the intracellular spaces of all the epithelial cells of the medullary collecting duct.
B. A disease that destroys all the G-proteins in all the epithelial cells of the medullary collecting duct.
C. A disease that destroys all the AQP2 Receptors in the basolateral membranes of all the epithelial cells of the medullary collecting duct.