Question 1:
The alkylation of "Evans" enolates is very highly diastereoselective as we have discussed, and shown below.
![2234_Alkylation of Evans.jpg](https://secure.tutorsglobe.com/CMSImages/2234_Alkylation%20of%20Evans.jpg)
Part 1. Show how Compound 1 is prepared from common starting materials.
Part 2. Explain the origins of the diastereoselectivity observed in Compound 2
Part 3. Show how Compound 2 is efficiently converted into Compound 3
Question 2:
Upon treatment with the strong base sodium hexamethyldisilazide (NaHMDS), one of the compounds shown undergoes intramolecular cyclization to give a tricyclic ketone.
The other compound does not cyclize. Indicate which compound will cyclize and provide an explanation for your selection.
![564_Alkylation of Evans1.jpg](https://secure.tutorsglobe.com/CMSImages/564_Alkylation%20of%20Evans1.jpg)