Question: Which of the following statements regarding the selection of a serotonin and norepinephrine reuptake inhibitor (SNRI) for the treatment of depression is correct? SNRIs are generally avoided in cases of comorbid anxiety disorders due to their anxiogenic effects. Duloxetine is an SNRI commonly used as a first-line treatment for depression and fibromyalgia Venlafaxine is the preferred SNRI for patients with a history of hypertension. Starting an SNRI at a high dose is recommended for rapid relief of depressive symptoms.