Assignment Task:
Please choose one essay title for each part and write your answers for each question as a 1500 words essay. Your work will thus comprise two parts of 1500 words, and the whole course work will be 3000 words.
Part A:
Option 1: Discuss the role of organelle quality control in maintaining mitochondria homeostasis and how its impairment may contribute to disease.
Option 2: Discuss the role of the respiratory system in maintaining cellular function and how its dysfunction may contribute to disease.
Part B:
Option 1: How can gene and cell therapy tackle infectious diseases?
To get started, refer to Hoxie & June (2012) Novel cell and gene therapies for HIV. Cold Spring Harb Prespect Med. doi: 10.1101/cshperspect.a007179.
Please also extend your reading to other reviews and articles for a wider perspective to your essay.
Option 2: Personalised gene and cell therapies are not sustainable treatment options against rare inherited diseases. Discuss.
To get started, refer to Kim et. al. (2019) Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. doi: 10.1056/NEJMoa1813279.
Please also extend your reading to other reviews and articles for more details in your essay.
Part C:
Option 1: The targeted use of biologics and synthetic DMARDs such as Baricitinib will improve the treatment of psoriatic arthritis.
Provide a critical discussion of this statement.
Option 2: Critically evaluate the role of cyclin-dependent kinases 4/6 inhibitors in cancer therapy.
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