question 1 which of the following is best control

Question

Question 1 Which of the following is best control group for double blind Phase II clinical trial? Justify your Answer.

1. Placebo Concurrent Control
2. No-treatment Concurrent Control
3. Dose-response Concurrent Control
4. Active Concurrent Control

Question 2 Briefly describe importance of blinding in clinical trials? Explain different types of blinding with an example?

Question 3 What are the statistical analysis methods available for clinical data? Which is the best statistical analysis method currently available? Justify your answer