Q. Working of serotonergic cell bodies?
The major site of serotonergic cell bodies is in upper pons and the midbrain, specifically the median and dorsal raphe nuclei and to a lesser extent in caudal locus ceruleus . These neurons serve to the basal ganglia, limbic system and cerebral cortex.
Receptors
Seven types of serotonin receptors have been recognised: 5-HT1 through 5-HT7 receptors with numerous subtypes, totaling 14 distinct receptors. 5HT1A receptors are widely distributed, concentrated in limbic areas (e.g., hippocampus and amygdala), in the cerebral cortex and also in raphé nuclei. Basal ganglia and hippocampus have 5HT1B receptors, and the 5HT1D receptor subtype is also evident in basal ganglia. 5HT2 or 5HT2A receptors are concentrated in cerebral cortex. 5HT3 receptors are present at low densities in cortex with highest densities in medulla and spinal cord.