q spontaneous deamination of cytosine 1, Biology

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q spontaneous deamination of cytosine 1

Q. Spontaneous deamination of cytosine:

1. Deamination of cytosine is common and results in conversion of cytosine to uracil 2. can be repaired by excision repair process (i) uracil-DNA glycosylase hydrolyzes N-glycosidic bond to remove uracil base (ii) AP endonuclease removes deoxyribose-phosphate (iii) gap is extended by exonuclease (iv) gap is filled by DNA polymerase I and nick is sealed by DNA ligase

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