Question 1) Structure and functions of biological membrane. Enlist different processes of drug transport across the biological membrane. Explain in detail specialised transport.
Question2) Describe the fate of drugs. Explain the role of microsomal enzyme system in biotransformation of drugs.
Question 3) Solve the following:
i) Describe the therapeutic index.
ii) Explain about bioavailability of drugs.
iii) Describe the term antagonism with suitable examples.
iv) Explain the first pass metabolism with suitable examples.
v) Explain how various pathological states modifying drug action.
vi) Explain the anaphylaxis.
vii) Explain the placental barrier
Question 4) Write a detailed note on the following:
i) G-protein coupled receptors (GPCR)
ii) Antiplatelet agents
iii) Drug treatment in pregnancy
iv) Fibric acid derivatives used as hypolipidimics
v) Types of gene therapy.
Question 5) Define and classify pneumonia. Explain the etiology, complications and clinical features of bacterial pneumonia.
Question 6) Explain cardiac arrhythmia. Discuss the pathophysiology of cardiac arrhythmia.
Question 7) Solve the following:
i) Explain the pathophysiology of chronic renal failure.
ii) Describe the pathophysiology of pain.
iii) Explain the pathophysiology of depression.
iv) Describe the etiology of malaria.
v) Pathophysiology of angina pectoris.
vi) Describe the complications of AIDS.
vii) Clinical features of type 1 and 2 diabetes mellitus.
Question 8) Write a brief note on the following:
i) Psychosis
ii) Sexually transmitted diseases
iii) Allergy
iv) Amoebic dysentery
v) Myocardial ischemia.