Question: Mr. Bowers is a 57 y/o male who was recently diagnosed with major depression and started on sertraline for his first trial of therapy. Screening tests only revealed a partial response to sertraline so he was switched to paroxetine for his second trial. After several weeks Mr. Bowers continued to have significant signs and symptoms of depression. Screening tests this time reflected less than a 25% decrease in his baseline symptoms. Based on this information, what would be the most appropriate treatment intervention? Augmentation with lithium Switching back to sertraline and maintaining for 12-36 months Continuation of paroxetine for at least 4- 9 months Switching to duloxetine